This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this pilot study is to collect preliminary data on the prevalence of carotid artery disease (CarAD) among asymptomatic childhood cancer survivors who received radiation to the neck and to explore its association with childhood disease/treatment factors and established cardiovascular (CV) rick factors.Thirty pediatric cancer survivors followed at Childrens Hospital Los Angeles and 30 healthy sibling/cousin controls will be enrolled in this study. We will use high-resolution B-mode ultrasounds to measure intima-,edial thickness (IMT) and arterial wall stiffness (AWS) of the carotid arteries and compare the results of cancer survivors to healthy controls. The results of this study will b e used to support the development of a larger prospective, longitudinal, multi-site study of CarAD pediatric oncology survivors who have received radiation therapy to the neck.
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