This pilot study will assess the effects of gender and exogenous hormones on hepatic cytochrome P450 3A4 activity in men and women. The primary objective is to compare the mean intrasubject coefficient of variation (C.V.) of the ratio of urinary 6-B-hydroxycortisol to cortisol (6-B-)H-cortisol:cortisol), determined over a four week period, among the three study groups: women not receiving exogenous hormones, women receiving Triphasil, and men. Secondary objectives include use of a second metabolic probe, dextromethorphan, and estrogen and progesterone concentrations to further assess these gender differences.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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