Persons with niddm, especially women, have abnormal oxygen consumption (vo2) responses to exercise even in the absence of clinical cardiovascular disease. We hypothesize that in persons with niddm compared to nondiabetic persons, decreased maximal and dynamic cardiac output and/or a-vo2 responses are associated with observed impaired vo2 responses. We also hypothesize that the decreased vo2 observed in niddm is associated with decreased levels of habitual physical activity level compared to control values. In addition, we hypothesize that exercise training will improve cardiovascular exercise performance and habitual physical activity level. Subjects will include 20 sedentary premenopausal women with uncomplicated niddm, 10 healthy women of similar weight, age and activity level and 10 lean women of similar age and activity level and 10 lean women of similar age and activity level as the women with niddm. We will compare the three groups using double-labeled water techniques. A four month exercise training program will follow the testing procedures with the tests to be repeated upon completion. The importance of these studies is l. To evaluate the underlying causes of the apparent cardiovascular abnormalities observed in uncomplicated niddm. 2. To evaluate the functional significance of these findings and 3. To evaluate the modifiability of the responses. This project will enable further understanding of the effects of diabetes on cardiovascular function during exercise as well as the functional significance of exercise impairment in diabetes.
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