This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a serious and increasing public health problem, and the proposed studies are expected to give important insight into the biology that predisposes individuals to weight gain and regain. The primary aims are a) to determine whether fat metabolism (lipolysis and/or oxidation) is impaired in obesity, and b) whether this can be reversed with weight loss. Exercise is advocated for obesity treatment, presumably through its potential to increase fat oxidation, but appears to have limited effectiveness. Evidence suggests that fat oxidation is blunted in obese and weight-reduced obese subjects during exercise. Thus, secondary aims are to determine in obese and weight-reduced obese humans whether fat metabolism during exercise is influenced by exercise intensity. Understanding how exercise regulates fat metabolism in obese and weight-reduced obese individuals is crucial in understanding the physiology of body weight regulation. Results from these studies could lead to additional studies to further explain why exercise may be important in the prevention and treatment of obesity.
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