This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The proposed study will definitively define the effect of statin treatment on whole body fuel homeostasis. Any changes identified will have immediate importance in understanding statin effects in man. More mechanistic studies can be immediately designed and implemented based on the results of this pilot study. Definition of the effects of statins on energy homeostasis has direct implications for understanding both the efficacy and putative toxicity of this important class of drugs. An effect of statins to shift fuel utilization from fatty acids to glucose might also be relevant to statin therapy in diabetics and reports of functional benefits of statins in ischemic syndromes, such as peripheral arterial disease, where glucose would represent a more efficient energy substrate.
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