Sleep-disordered breathing is a common and serious cause of morbidity during childhood. Though the diagnosis of frank obstructive sleep apnea syndrome (OSAS) is readily achieved by overnight polysomnography, the recognition of more subtle forms of obstructed breathing, such as the upper airway resistance syndrome (UARS) are not. UARS is characterized by brief, repetitive arousals during sleep associated with increased respiratory effort, in the absence of overt apnea/hypopnea or gas exchange abnormalities. The diagnosis of UARS is important insofar as it has been associated with profound physiological and neurobehavioral consequences. The """"""""gold standard"""""""" for diagnosing UARS is esophageal manometry, which is invasive and cumbersome. Our research proposal hypothesized that the physiological determinants of sleep-disordered breathing in children could be characterized using non-invasive measures of flow limitation, respiratory effort and autonomic arousal. Otherwise normal children between 2 - 6 years of age who presented to the outpatient clinic with symptoms of sleep-disordered breathing were asked to participate in the study. Subjects underwent a standard overnight polysomnographic montage with the addition of esophageal manometry recording, pulse transit time measurement, respiratory inductance plethysmography and heart rate variability analysis. The definitive diagnose of sleep-disordered breathing, including UARS was made using esophageal manometry, which was then compared with the noninvasive indices. The ability to diagnose UARS using noninvasive tools will extend treatment options to many children with physiological and neurocognitive sequelae of sleep-disordered breathing.
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
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