This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LSOCA is a multicenter, prospective, observational study of patients with AIDS for the occurrence of ocular complications (e.g. opportunistic ocular infections) and for the long-term outcomes of these complications. Patients with a diagnosis of AIDS according to the 1993 CDC criteria, with or without ocular complications, will be enrolled. All patients will be seen on a three- month follow-up schedule. For patients with a major ocular complications, all follow-up visits will be clinic visits. For patients without a major ocular complication, follow-up visits will alternate between telephone follow-up visits and clinic visits. Data will be collected from eye examinations, fundus photographs, visual function testing, medical history, quality of life assessment, laboratory studies, and collection of plasma and blood cells for banking. Banked specimens will be analyzed for Human Immunodeficiency Virus (HIV) RNA levels and cytomegalovirus (CMV) DNA levels. Outcomes of interest include the incidence of CMV retinitis, incidence of other ocular complications, mortality, incidence of extra-ocular CMV disease, and the sequelae of AIDS-related eye disease (e.g., retinal detachment), visual function, quality of life, and incidence of complications of therapies for ocular complications.
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