Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL049566-05
Application #
2225651
Study Section
Special Emphasis Panel (ZHL1-CSR-J (01))
Project Start
1992-09-30
Project End
1997-06-30
Budget Start
1996-05-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Jung, Sonia S; Zhang, Weibing; Van Nostrand, William E (2003) Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J Neurochem 85:1208-15
Davis, Judianne; Wagner, Matthew R; Zhang, Weibing et al. (2003) Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells. J Biol Chem 278:19054-61
Van Nostrand, William E; Melchor, Jerry P; Keane, David M et al. (2002) Localization of a fibrillar amyloid beta-protein binding domain on its precursor. J Biol Chem 277:36392-8
Mahdi, F; Rehemtulla, A; Van Nostrand, W E et al. (2000) Protease nexin-2/Amyloid beta-protein precursor regulates factor VIIa and the factor VIIa-tissue factor complex. Thromb Res 99:267-76
Van Nostrand, W E; Melchor, J; Wagner, M et al. (2000) Cerebrovascular smooth muscle cell surface fibrillar A beta. Alteration of the proteolytic environment in the cerebral vessel wall. Ann N Y Acad Sci 903:89-96
Wagner, M R; Keane, D M; Melchor, J P et al. (2000) Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa. Biochemistry 39:7420-7
Hook, V Y; Sei, C; Yasothornsrikul, S et al. (1999) The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J Biol Chem 274:3165-72
Annich, G; White, T; Damm, D et al. (1999) Recombinant Kunitz protease inhibitory domain of the amyloid beta-protein precursor as an anticoagulant in venovenous extracorporeal circulation in rabbits. Thromb Haemost 82:1474-81
Van Nostrand, W E; Porter, M (1999) Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity. Biochemistry 38:11570-6
Van Nostrand, W E; Melchor, J P; Ruffini, L (1998) Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. J Neurochem 70:216-23

Showing the most recent 10 out of 24 publications