This phase I-II study is designed to evaluate oral tolerance and efficacy of a novel peripheral opioid antagonist, methylnaltrexone. This pharmacokinetics based study will allow us to obtain first ever information of oral dose methylnaltrexone in preventing opioid-induced changes in gastrointestinal motility and transit in healthy human volunteers. Methylnaltrexone was discovered by researchers at the University of Chicago.

Project Start
1997-01-06
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
36
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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