1) To test the hypotheses that IV methylnaltrexone can be safely used in reversing methadone-induced gastrointestinal motility changes without withdrawal symptoms in subjects receiving chronic methadone therapy. 2) To test the hypotheses that IV methylnaltrexone can be used in treatment (or prevention) of opioid-induced constipation without interfering with analgesia in chronic pain patients with metastatic malignancy.
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| Copinschi, Georges; Leproult, Rachel; Spiegel, Karine (2014) The important role of sleep in metabolism. Front Horm Res 42:59-72 |
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