Safety and Efficacy of Recombinant DNA Factor Viii in Hemophilia a Patients

Kisker, Thomas C.

Abstract

A multicenter open label cross over comparison of in vivo half-life and recovery of a recombinant Factor VIII preparation with the standard, plasma derived, purified Factor VIII in non bleeding patients, followed by a long term evaluation of the safety, tolerance, and efficacy of the recombinant preparation.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000059-29
• Application #: 3884016
• Support Year: 29
• Fiscal Year: 1990

Institution

• Name: University of Iowa
• DUNS #: 041294109
• City: Iowa City
• State: IA
• Country: United States
• Zip Code: 52242

Publications

Rao, Satish S C; Valestin, Jessica A; Xiang, Xuelian et al. (2018) Home-based versus office-based biofeedback therapy for constipation with dyssynergic defecation: a randomised controlled trial. Lancet Gastroenterol Hepatol 3:768-777

Curtis, Alexandra M; VanBuren, John; Cavanaugh, Joseph E et al. (2018) Longitudinal associations between dental caries increment and risk factors in late childhood and adolescence. J Public Health Dent 78:321-328

Lorenz, Douglas J; Levy, Steven; Datta, Somnath (2018) Inferring marginal association with paired and unpaired clustered data. Stat Methods Med Res 27:1806-1817

Oweis, Reem Reda; Levy, Steven M; Eichenberger-Gilmore, Julie M et al. (2018) Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study. Community Dent Oral Epidemiol 46:527-534

Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264

Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201

Choo-Wosoba, Hyoyoung; Gaskins, Jeremy; Levy, Steven et al. (2018) A Bayesian approach for analyzing zero-inflated clustered count data with dispersion. Stat Med 37:801-812

Levy, Steven M; Eichenberger-Gilmore, Julie M; Warren, John J et al. (2018) Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11. J Public Health Dent 78:352-359

Spracklen, Cassandra N; Ryckman, Kelli K; Robinson, Jennifer G et al. (2017) Low Birth Weight and Risk of Later-Life Physical Disability in Women. J Gerontol A Biol Sci Med Sci 72:543-547

Reber, Justin; Tranel, Daniel (2017) Sex differences in the functional lateralization of emotion and decision making in the human brain. J Neurosci Res 95:270-278