Life-threatening ventricular tachycardia (VT) remains a major complication of myocardial infarction. The VT substrate is diseased myocardium that slows local conduction sufficiently to perpetuate circuit reentry. This proposal aims to enhance our understanding of the anatomic details of the VT substrate and its effects upon patient response to antiarrhythmic drug therapy and catheter ablation, an alternative mode of therapy that aims to destroy the VT substrate. Currently, ablation is performed by use of local, point-by-point acquired, intra- cardiac electrograms, which serve as surrogates for each patient's unique VT substrate. This strategy is limited by low sampling density and lack of specificity. Direct evaluation of the anatomic VT substrate has recently become feasible with imaging techniques such as computed tomography (CT). We propose a time-sensitive ancillary study to the Ventricular Tachycardia Ablation vs. Enhanced Drug Therapy In Structural Heart Disease (VANISH) and the Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients with Implantable Cardioverter Defibrillators (ASPIRE) multicenter randomized clinical trials. We will acquire resting myocardial CT perfusion and delayed contrast-enhanced CT infarct imaging in 200 VANISH and ASPIRE participants prior to randomization, and at 1-year follow-up. The data will be used to a) define anatomic features that predict the optimal mode of VT therapy thereby allowing proper selection of ablation versus antiarrhythmic drugs, b) define the anatomic details of slow conduction VT substrates, c) determine the substrate changes necessary for VT suppression, and d) characterize the resultant cardiac remodeling from ablation versus drug therapy. We have assembled a team of experts in CT image acquisition and analysis, epidemiology, biostatistics, and VT management. The findings of this study will have wide applicability to optimization of management strategies for patients with post-infarct VT.

Public Health Relevance

Up to 18% of the 120,000 US patients who undergo defibrillator implantation every year will require ventricular tachycardia suppression within a yea of implant. The proposed computed tomography ancillary study provides a unique opportunity to study the post-infarct ventricular tachycardia substrate and the implications of that substrate on therapy selection for optimal VT suppression and preservation of cardiac function.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL116280-03
Application #
8894566
Study Section
Special Emphasis Panel (ZHL1-CSR-S (F1))
Program Officer
Boineau, Robin
Project Start
2013-08-05
Project End
2017-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
3
Fiscal Year
2015
Total Cost
$292,893
Indirect Cost
$57,358
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Zghaib, Tarek; Shahid, Adeel; Pozzessere, Chiara et al. (2018) Validation of contrast-enhanced time-resolved magnetic resonance angiography in pre-ablation planning in patients with atrial fibrillation: comparison with traditional technique. Int J Cardiovasc Imaging 34:1451-1458
Xie, Shuanglun; Desjardins, Benoit; Kubala, Maciej et al. (2018) Association of regional epicardial right ventricular electrogram voltage amplitude and late gadolinium enhancement distribution on cardiac magnetic resonance in patients with arrhythmogenic right ventricular cardiomyopathy: Implications for ventricular ta Heart Rhythm 15:987-993
Huang, Dong; Li, Jing-Bo; Zghaib, Tarek et al. (2018) The Extent of Left Atrial Low-Voltage Areas Included in Pulmonary Vein Isolation Is Associated With Freedom from Recurrent Atrial Arrhythmia. Can J Cardiol 34:73-79
Zghaib, Tarek; Malayeri, Ashkan A; Ipek, Esra G et al. (2018) Visualization of acute edema in the left atrial myocardium after radiofrequency ablation: Application of a novel high-resolution 3-dimensional magnetic resonance imaging sequence. Heart Rhythm 15:1189-1197
Zghaib, Tarek; Ipek, Esra G; Hansford, Rozann et al. (2018) Standard Ablation Versus Magnetic Resonance Imaging-Guided Ablation in the Treatment of Ventricular Tachycardia. Circ Arrhythm Electrophysiol 11:e005973
Zghaib, Tarek; Keramati, Ali; Chrispin, Jonathan et al. (2018) Multimodal Examination of Atrial Fibrillation Substrate: Correlation of Left Atrial Bipolar Voltage Using Multi-Electrode Fast Automated Mapping, Point-by-Point Mapping, and Magnetic Resonance Image Intensity Ratio. JACC Clin Electrophysiol 4:59-68
Zghaib, Tarek; Ghasabeh, Mounes Aliyari; Assis, Fabrizio R et al. (2018) Regional Strain by Cardiac Magnetic Resonance Imaging Improves Detection of Right Ventricular Scar Compared With Late Gadolinium Enhancement on a Multimodality Scar Evaluation in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy. Circ Cardiovasc Imaging 11:e007546
Wang, Linwei; Gharbia, Omar A; Nazarian, Saman et al. (2018) Non-invasive epicardial and endocardial electrocardiographic imaging for scar-related ventricular tachycardia. Europace 20:f263-f272
Huang, Dong; Marine, Joseph E; Li, Jing-Bo et al. (2017) Association of Rate-Dependent Conduction Block Between Eccentric Coronary Sinus to Left Atrial Connections With Inducible Atrial Fibrillation and Flutter. Circ Arrhythm Electrophysiol 10:
Nazarian, Saman; Hansford, Rozann; Rahsepar, Amir A et al. (2017) Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices. N Engl J Med 377:2555-2564

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