The effects of vitamin E on the prevention and treatment of progressive liver disease, Ig A nephropathy (nephritis marked by inflamation of the renal capillaries). Dietary supplementation with vitamin E in a study with an Ig A rat model indicated that blood and calcium in the urine was thinned, renal blood flow was stabilized, and lipid peroxidation (high oxidation) of the renal parenchyma (essential tissue) was reduced. These findings suggest that increased vitamin E intake could modulate progressive renal injury in this disease state. The study will use children with Ig A nephropathy so as to test the effects of early treatment on this slowly progressive disease. Supplemental vitamin E will be given daily for two years to children with Ig A nephropathy in a double blind, placebo-controlled experimental design. The primary aim will be the incidence of hematuria (blood in the urine). Secondary aims will be changes in microalbuminaria (albumin in the urine), and glomerular filtration rate. Measurements of urinary erythrocytes (red blood cells) will be made before treatment and at four month intervals for the duration of the study. A dosage of 400 IU per day will be given to children weighing less than 30 kg. To children weighing more, a dosage of 2 x 400 IU per day will be given. Research material will be obtained from the patients and their medical records and it will be characterized by creatinine clearance, proteinuria, urinalysis, and index renal biopsies in addition to the routine, every fourth monthly biochemical determinations.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Virginia Commonwealth University
United States
Zip Code
Holkova, Beata; Yazbeck, Victor; Kmieciak, Maciej et al. (2017) A phase 1 study of bortezomib and romidepsin in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma, indolent B-cell lymphoma, peripheral T-cell lymphoma, or cutaneous T-cell lymphoma. Leuk Lymphoma 58:1349-1357
Eaton, J E; Juran, B D; Atkinson, E J et al. (2015) A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease. Aliment Pharmacol Ther 41:980-90
Worthington Jr, Everett L; Berry, Jack W; Hook, Joshua N et al. (2015) Forgiveness-reconciliation and communication-conflict-resolution interventions versus retested controls in early married couples. J Couns Psychol 62:14-27
Corey, Kathleen E; Vuppalanchi, Raj; Vos, Miriam et al. (2015) Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 60:360-7
Holkova, Beata; Kmieciak, Maciej; Perkins, E Brent et al. (2014) Phase I trial of bortezomib (PS-341; NSC 681239) and ""nonhybrid"" (bolus) infusion schedule of alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms. Clin Cancer Res 20:5652-62
Lo, D J; Farris, A B; Song, M et al. (2013) Inhibition of ?v?6 promotes acute renal allograft rejection in nonhuman primates. Am J Transplant 13:3085-93
Jones, Robert; Vuky, Jacqueline; Elliott, Tony et al. (2013) Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer. Invest New Drugs 31:1001-7
Al Hawaj, M A; Martin, E J; Venitz, J et al. (2013) Monitoring rFVIII prophylaxis dosing using global haemostasis assays. Haemophilia 19:409-14
Noureddin, Mazen; Yates, Katherine P; Vaughn, Ivana A et al. (2013) Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients. Hepatology 58:1644-54
Lo, D J; Anderson, D J; Weaver, T A et al. (2013) Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion. Am J Transplant 13:320-8

Showing the most recent 10 out of 367 publications