This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Background: Insulin resistance is the hallmark of pathogenesis of a number of chronic disorders and have become a major health concern. Finding an alternative non-invasive test that is both easy to administer and accurate may lead to earlier detection of insulin resistance, thus enabling individuals to seek earlier cost preventative treatment options.
Specific Aims and Procedures: The long term objective to develop a non-invasive test of insulin resistance. Experimental Design: Each subject will have a screening period and based on those results will be asked to return for a hospital admission at which time the OGTT and the breath test will be completed. All admitted subjects will receive a peripherial IV for blood sampling. The OGTT is administered by giving the subject 75 grams of Glucola following 2 baseline blood samples. The test then continues for 10 hours with blood sampling at selected time points. The breath samples will be collected at the same time points as the OGTT. The subject will be asked to take a full breath and then the entire breath is exhaled through a straw into a tube. Before exhaling completely, the straw is withdrawn and the screw cap is replaced on the tube.Significance: A successful outcome of this research will lead to the scientific basis for manufacturing a product that will help to accurately detect insulin resistance by using a noninvasive technique.
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