This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of core blood as a source of stem cells for bone marrow transplantation has become increasingly popular, both due to its relative availability and to the greater capacity of core blood hematopoietic progenitor cells to produce colonies compared with those from adult bone marrow (BM)(1-4). However, the biology of cord blood progenitor cells is not well understood. We have observed that cord blood CD34 cells have a high expression of the surface adhesion molecule, L-selectin, and that its expression on CD34 cells is linked with an increased production of myeloid cells (5). In preliminary studies we have observed that a diminished proportion of adult BM CD34 cells co-express L-selectin compared with those of cord blood. Therefore, one goal of this study is to define the role of L-selectin, in addition to mediating cell adhesion, is involved in cell signaling. Recent reports have linked activation of L-selectin on leukocytes with a decreased rate of apoptosis (6).
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