Abstract

The primary objective of this study is to test the hypothesis that once-daily infusions of LY333328 provide clinically successful treatment equivalent to that of Vancomycin in patients hospitalized on the Surgical Service with complicated gram-positive bacterial skin infections. The secondary objectives of this study are to: compare the safety parameters among the treatment regimens; characterize population pharmacokinetics of the study drug in patients, and to explore potential factors that may influence variability of pharmacokinetics; and to explore the association of pharmacokinetic variables with efficacy and safety parameters. The GCRC nursing staff obtain and process the samples for the pharmacokinetic study when the investigator's team not available.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000083-38
Application #
6415087
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1974-10-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79
Abid, Z; Oh, S S; Hu, D et al. (2016) Maternal age and asthma in Latino populations. Clin Exp Allergy 46:1398-1406
Rahmani, Elior; Zaitlen, Noah; Baran, Yael et al. (2016) Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods 13:443-5
Morrissey, Kari M; Stocker, Sophie L; Chen, Eugene C et al. (2016) The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet 55:495-506
Wright, Patrick W; Pyakurel, Ashmit; Vaida, Florin F et al. (2016) Putamen volume and its clinical and neurological correlates in primary HIV infection. AIDS 30:1789-94
Peters, Marion G; Bacchetti, Peter; Boylan, Ross et al. (2016) Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV. AIDS 30:723-9
Gonzales, C A; Bacchetti, P; Khalili, M (2016) Impact of gender and menopausal status on metabolic parameters in chronic hepatitis C infection. J Viral Hepat 23:232-9
Zhi, Degui; Shendre, Aditi; Scherzer, Rebecca et al. (2015) Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals. J Hum Genet 60:63-7
Wright, Patrick W; Vaida, Florin F; Fernández, Ricardo J et al. (2015) Cerebral white matter integrity during primary HIV infection. AIDS 29:433-42

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