Abstract

Elevated levels of TNFa can produce fevers, malaise and weight loss in patients with mycobacterial infections or HIV. Thalidomide selectively reduces the serum levels of TNFa in these patients and may alleviate their symptoms. The metabolic effects of thalidomide that would arrest weight loss and allow patient to return to normal weight have not yet been elucidated. We admitted patients to the GCRC and established them on a metabolic diet. Patients were then treated with thalidomide. A longitudinal evaluation of metabolic function was undertaken to examine the impact of thalidomide. These studies are preliminary and require more patients for statistical validity. We plan to continue to refine our evaluations to understand more about the effects of both thalidomide and TNFa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000102-33
Application #
5219566
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Barbuto, Scott; Idoyaga, Juliana; Vila-Perelló, Miquel et al. (2013) Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nat Chem Biol 9:250-6
Guo, Xiuyang; Dhodapkar, Kavita M (2012) Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells. Hum Immunol 73:871-8
Dustin, Lynn B; Charles, Edgar D (2012) Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. Antivir Ther 17:1449-52
Pendyala, Swaroop; Walker, Jeanne M; Holt, Peter R (2012) A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142:1100-1101.e2

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