The goal of this study is to activate these latent cells non-specifically using a potent agent, ORTHOCLONE OKT(R)3, a murine monoclonal antibody which on binding to the CD3 molecule on the surface of a T cell causes a cascade of phosphorylation events leading to T cell activation, cytokine release, and HIV expression in latently infected cells. Under the coverage of highly effective antiretroviral therapy, these cells should produce non-infectious particles and once activated die quickly.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
37
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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