This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This trial will examine the performance of 40 single unit crowns (25 posterior and 15 anterior) for a period of at least 2 years. Crowns will be fabricated from a lithium disilicate glass-ceramic using a computer-aided design/computer-aided machining (CAD/CAM) process. Both the material and the processing equipment have FDA 510-K clearance for this clinical application. The PI initiated this trial at UConn as an important complement to ongoing laboratory efforts to better understand clinical behavior and aid ongoing research into the development of validated laboratory tests of ceramic-ceramic compatibility and bulk fracture.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006192-13
Application #
7377358
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
13
Fiscal Year
2006
Total Cost
$41,369
Indirect Cost
Name
University of Connecticut
Department
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
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