This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with diabetes benefit from self glucose monitoring. Current techniques for performing self glucose monitoring require piercing the skin with a lancet to obtain a droplet of blood. Because of this, they are associated with some discomfort and a small risk of infection. This study tests whether it is possible to monitor glucose non-invasively by measuring glucose levels in fluid that is collected from the air that is expired during normal breathing (this fluid is called the exhaled breath condensate or EBC). This proof of concept study will proceed in two phases. The first phase will attempt to demonstrate that glucose can be measured in EBC and that it is correlated with blood glucose measurements. EBC will be collected using a standard non-invasive apparatus in volunteers with diabetes and non-diabetic controls. EBC glucose will be compared to capillary blood glucose measurements (finger stick method) and plasma glucose measurements. If this phase successfully demonstrates that glucose can be measured in EBC and that it reflects capillary and plasma glucose levels, then the second phase of testing will be performed. In the second phase, the response of EBC glucose to physiological changes in plasma glucose will be assessed. EBC will be collected before and during a standard 75-gram oral glucose tolerance test in patients with diabetes and non-diabetic controls. The time course of changes in EBC glucose will be compared to those of capillary and plasma glucose levels. The information gathered from this study will provide information that may lead to the development of a non-invasive glucose monitor, based on the principle of EBC glucose measurements, for patients with diabetes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000109-45
Application #
7952116
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2009-03-01
Project End
2010-02-28
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
45
Fiscal Year
2009
Total Cost
$10,259
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Scagnelli, Connor N; Howard, Diantha B; Bromberg, Mark B et al. (2018) Hydration measured by doubly labeled water in ALS and its effects on survival. Amyotroph Lateral Scler Frontotemporal Degener 19:220-231
Horne, Hisani N; Sherman, Mark E; Pfeiffer, Ruth M et al. (2016) Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease. Breast Cancer Res 18:24
Kien, C Lawrence; Matthews, Dwight E; Poynter, Matthew E et al. (2015) Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of ?-oxidation. J Lipid Res 56:1795-807
Gierach, Gretchen L; Patel, Deesha A; Falk, Roni T et al. (2015) Relationship of serum estrogens and metabolites with area and volume mammographic densities. Horm Cancer 6:107-19
Albert, Kimberly; Pruessner, Jens; Newhouse, Paul (2015) Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle. Psychoneuroendocrinology 59:14-24
Bodelon, Clara; Heaphy, Christopher M; Meeker, Alan K et al. (2015) Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy. BMC Cancer 15:823
Morris, Erin A; Hale, Sarah A; Badger, Gary J et al. (2015) Pregnancy induces persistent changes in vascular compliance in primiparous women. Am J Obstet Gynecol 212:633.e1-6
Miller, Mark S; Bedrin, Nicholas G; Ades, Philip A et al. (2015) Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area. Am J Physiol Cell Physiol 308:C473-84
Kien, C Lawrence; Bunn, Janice Y; Fukagawa, Naomi K et al. (2015) Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem 26:1599-606
Wills, Anne-Marie; Hubbard, Jane; Macklin, Eric A et al. (2014) Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 383:2065-2072

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