The specific aims of this study are to measure gastric, small bowel, and colonic transit in 18 healthy volunteers randomized to placebo, 30 ug, or 60 ug, t.i.d. of pramlintide, and to measure gastric emptying in 6 type I diabetics and 6 type II diabetics in response to placebo, 30 ug, or 60 ug, t.i.d. of pramlintide. Our hypotheses is that pramlintide dose dependently retards gastric emptying without altering small bowel or colonic transit in health, 30 ug, t.i.d. (low dose) of pramlintide retards gastric emptying in type I diabetes mellitus, and 60 ug, t.i.d. (high dose) of pramlintide retards gastric emptying in both type I and type II diabetes mellitus.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000585-29
Application #
6409651
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1976-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
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