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Abstract

The purpose of this investigation is to assess virologic, environmental, and host factors that affect the progression of chronic hepatitis C virus (HCV) infection. The General Clinical Research Center at Johns Hopkins has been utilized to evaluate the principle outcome for this investigation, liver failure as determined by physical examination and liver biopsy. Since the beginning, NIH funding for this project has been received (1U19 AI 40035-01) and more than 30 liver biopsies have been completed. A preliminary analysis of the effect of HIV infection on HCV progression was published in the Journal of Infectious Diseases (Thomas, et al. 1996; 174: 690-95).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000722-24
• Application #: 2353461
• Budget Start: 1995-10-01
• Budget End: 1996-09-30
• Support Year: 24
• Fiscal Year: 1996

Institution

• Name: Johns Hopkins University
• DUNS #: 045911138
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Tipton, Laura; Cuenco, Karen T; Huang, Laurence et al. (2018) Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min 11:12

Juraschek, Stephen P; Woodward, Mark; Sacks, Frank M et al. (2017) Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet. Hypertension 70:923-929

Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40

Tang, Olive; Miller 3rd, Edgar R; Gelber, Allan C et al. (2017) DASH diet and change in serum uric acid over time. Clin Rheumatol 36:1413-1417

Juraschek, Stephen P; Miller 3rd, Edgar R; Weaver, Connie M et al. (2017) Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure. J Am Coll Cardiol 70:2841-2848

Segal, Leopoldo N; Clemente, Jose C; Tsay, Jun-Chieh J et al. (2016) Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol 1:16031

Aziz, Najib; Detels, Roger; Quint, Joshua J et al. (2016) Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions. Cytokine 84:17-24

Cribbs, Sushma K; Uppal, Karan; Li, Shuzhao et al. (2016) Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection. Microbiome 4:3

Juraschek, Stephen P; Gelber, Allan C; Choi, Hyon K et al. (2016) Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis Rheumatol 68:3002-3009

Aziz, Najib; Detels, Roger; Chang, L Cindy et al. (2016) Macrophage Inflammatory Protein-3 Alpha (MIP-3?)/CCL20 in HIV-1-Infected Individuals. J AIDS Clin Res 7: