Music has been postulated as an effective pain intervention strategy. Neurophysiological pathways have been identified which support that music should produce an endorphin response. Based on neuron-to-neuron interactions and neuronal projections to various brain regions, audiostimulation, via self-selected music, is expected to produce an elevation in endogenous opioids, specifically beta-endorphin. However, no studies have reported whether persons who have pain and listen to music exhibit a decrease in pain intensity accompanied by an increase in beta-endorphin levels. The purpose of the study is to determine if beta- endorphin is released in response to self-selected music. The quasi- experimental study of 30 subjects will measure plasma endorphin levels and pain response at timed intervals. Three experimental conditions will include pain alone, music alone, and a combination of pain and music experienced one week apart, providing a total of 90 measurement points. Plasma endorphin, pain intensity and distress, and physiological parameters will be measured in response to an electrical pain stimulus via a Grass Stimulator. Beta-endorphin will be measured by radioimmunoassay; pain response measured by heart rate, blood pressure, oxygen saturation, and self-report of pain intensity and distress using an 11-point numerical scale and verbal descriptor scales respectively. The Spacelab 2000 hemodynamic monitor will measure physiological variables and allowed for trending of responses to the experimental conditions across time and to permit comparison of response patterns among the testing situations. Data analysis using SPSS statistical software will employ ANOVA with repeated measures The study provides initial support for the mechanism which subserves the efficacy of music to relieve pain.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
26
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Robinson-Cohen, Cassianne; Bartz, Traci M; Lai, Dongbing et al. (2018) Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. J Am Soc Nephrol 29:2583-2592
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Gupta, Samir K; Yeh, Eunice; Kitch, Douglas W et al. (2017) Bone mineral density reductions after tenofovir disoproxil fumarate initiation and changes in phosphaturia: a secondary analysis of ACTG A5224s. J Antimicrob Chemother 72:2042-2048
Robarge, Jason D; Desta, Zereunesay; Nguyen, Anne T et al. (2017) Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer. Breast Cancer Res Treat 161:453-461
Hertz, Daniel L; Speth, Kelly A; Kidwell, Kelley M et al. (2017) Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients. Breast Cancer Res Treat 165:659-668
Patel, Yash R; Kirkman, M Sue; Considine, Robert V et al. (2017) Retinopathy predicts progression of fasting plasma glucose: An Early Diabetes Intervention Program (EDIP) analysis. J Diabetes Complications 31:605-610
Robarge, Jason D; Metzger, Ingrid F; Lu, Jessica et al. (2017) Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition. Antimicrob Agents Chemother 61:
Hertz, D L; Kidwell, K M; Seewald, N J et al. (2017) Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer. Pharmacogenomics J 17:521-527
Kadakia, Kunal C; Kidwell, Kelley M; Seewald, Nicholas J et al. (2017) Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors. Breast Cancer Res Treat 164:411-419

Showing the most recent 10 out of 767 publications