The aim of the proposed project is to further define the natural history of nephrocalcinosis (calcifications within kidney tissue) in the premature infant and to identify factors which would distinguish infants most at risk. Some infants who develop nephrocalcinosis resolve spontaneously, without treatment, while others have persistent calcium deposits in the kidney which do not resolve. Currently, there is no way to predict which infants will have persistent nephrocalcinosis, and it is not clear whether this persistent nephrocalcinosis is of any clinical significance. Preliminary studies showed that a markedly elevated urinary calcium-to- creatinine ratio may be predictive of which patients will have persistent nephrocalcinosis. The current project proposes to screen a specific group of premature infants most at risk for developing nephrocalcinosis and follow them for two years after birth. The work proposed in this study will allow children at risk to be identified much earlier in their lives, with the hopes that earlier identification will allow more aggressive treatment and follow-up. This work will also better define the premature infant population which does not develop nephrocalcinosis, giving future investigators a much better control group reference.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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