Antisense technology (treatment directed against blocking """"""""sense"""""""" m RNA) represents a novel approach to the treatment of cancer and other proliferative diseases. The H-ras oncogene and its protein product are know to play an important role in the development and progression of many cancers. The study will determine the maximum tolerated dose of ISIS 2503 in patients with advanced cancer when administered as a weekly 24-hour continuous i.v. infusion. The secondary objectives of this study are to characterize the safety profile and pharmacokinetic and pharmacodynamic of ISIS 2503 when administered as a weekly 24-hour continuous i.v. infusion.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
28
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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