This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the effects of pioglitazone therapy in type 2 diabetics on fluid balance, peripheral edema, and body weight. Determine the mechanisms by which pioglitazone treatment influences fluid balance, edema and body weight, independent of effects on glycemic control
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