This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ascertain a minimum of 420 pedigrees from 7 sites and 5 years of the project with a proband who has schizophrenia by DSM-IV criteria. Obtain the following robust and quality assured phenotype measures in this sample, in addition to a structured DIGS diagnosis: P50 suppression, prepulse inhibition of acoustic startle, antisaccade, continuous performance test, verbal memory and working memory. Perform complex segregation analyses. Perform a genomee scan with polymorphic markers. Model a neurobiological basis of risk for schizophre
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