This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
SPECIFIC AIMS Although functional in the case of acute inflammation, we posit that the immune response induced by the potent and unique stressor of pain has important health implications for those patients with chronic inflammatory diseases, including atherosclerosis, inflammatory bowel disease, and rheumatoid arthritis. Understanding how pain may contribute to the pathology and symptomatology of such diseases is clearly an area worthy of nursing investigation. To this end, the specific aims of this preliminary work are to: 1 Via a formal pilot study, describe and compare the particular immune and inflammatory system responses (including changes in catecholamines, cytokines, and cellular adhesion molecules) in healthy male and female controls to experimental pain stress conditions. 2. Develop a new line of investigation for the principal investigator, who will expand her expertise in pain physiology to include the effects of pain on immune and inflammatory parameters, via multidisciplinary collaboration with nationally-recognized neurophysiologists and immunologists. The proposed pilot study will test the novel idea that pain, as a unique stressor, has detrimental effects via inflammatory processes via its effect on increasing CAM levels. Study hypotheses are based upon a stress framework, in which pain is conceptualized as both a psychological (affective) stressor and a uniquely nociceptive (neural-sensory) stressor, the effects of which are evident in adrenergic markers, cytokine production, and ultimately CAM levels.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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Special Emphasis Panel (ZRR1-CR-4 (01))
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Ellsworth, G B; Lensing, S Y; Ogilvie, C B et al. (2018) A delayed dose of quadrivalent human papillomavirus vaccine demonstrates immune memory in HIV-1-infected men. Papillomavirus Res 6:11-14
Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295
Dean, Andy C; Morales, Angelica M; Hellemann, Gerhard et al. (2018) Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness. Neuropsychopharmacology 43:1745-1752
Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79
Lee, Chioun; Coe, Christopher L; Ryff, Carol D (2017) Social Disadvantage, Severe Child Abuse, and Biological Profiles in Adulthood. J Health Soc Behav 58:371-386
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809

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