This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death and the leading cause of disability in older people. The long-term goal of this study is to determine factors that effect cerebral vasoregulation after stroke. The primary hypothesis is that cerebral vasoregulation is impaired in older adults with stroke and cerebral blood flow is dependent on blood pressure. Therefore, cerebral perfusion pressure may be different in stroke-normotensive and stroke-hypertensive patients in upright position. The second hypothesis is that autonomic blood pressure control is altered after stroke, predisposing older people to orthostatic hypotension (OH) and cerebral hypoperfusion during activities of daily living. The third hypothesis is that regional distribution of impaired vasoreactivity may extend beyond the infarct site and cerebral blood flow may be further compromised by white matter changes.
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