This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Cerebellar-Type Multiple System Atrophy (MSA-C) is a rapidly-progressive sporadic cerebellar ataxia which can be hard to distinguish from other cerebellar ataxias. Recently, a study of 5 MSA-C patients revealed that the arginine challenge test may distinguish MSA from other cerebellar ataxias. We will repeat this study on 30 MSA-C patients, 30 non-MSA ataxics, 30 not yet diagnosed ataxics, and 30 normal controls. Thus, we will confirm or reject the utility of the arginine challenge test for the diagnosis of MSA-C.
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