This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study to determine which areas of the cerebral cortex and mid-brain are activated and deactivated when the sensation of thirst and desire to drink dominate the stream of consciousness. Thirst will be produced in normal subjects (age 18-30 and 75-85) by intravenous infusion of a small amount of stock 0.85 M saline at a rate which will contrive a rise in plasma [Na] of 3-4% over a period of 40 minutes. The primary purpose of the study will be to image two groups of disparate age (young and old) when they are normally hydrated, then image during infusion of concentrated salt at a rate sufficient to raise the blood salt concentration by 3-4%. A total of 40 subjects will have PET blood flow scans and MRI anatomical scans, physical examination, neuropsychological and psychophysical evaluation.
Showing the most recent 10 out of 600 publications
