Research will test the hypothesis that free enantiomeric warfarin concerntrations, categorized according to vitamin K concentrations (and/or dietary intake) are the best clinical predictors for warfarin's pharmacologic response in geriatric stroke patients.
Aims are: l. Determine, in geriatric stroke patients, pharmacokinetic parameters (area under the curve and oral clearance) for racemic (total and free) and enantiomeric (total and free) warfarin. 2. Measure warfarin's response time in ger. stroke patients using (PT) and INR).

Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
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