Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS033731-02
Application #
2272701
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Ubach, J; Garcia, J; Nittler, M P et al. (1999) Structure of the Janus-faced C2B domain of rabphilin. Nat Cell Biol 1:106-12
Shao, X; Fernandez, I; Sudhof, T C et al. (1998) Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? Biochemistry 37:16106-15
Zhang, X; Rizo, J; Sudhof, T C (1998) Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry 37:12395-403
Rizo, J; Sudhof, T C (1998) C2-domains, structure and function of a universal Ca2+-binding domain. J Biol Chem 273:15879-82
Ubach, J; Zhang, X; Shao, X et al. (1998) Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? EMBO J 17:3921-30
Shao, X; Li, C; Fernandez, I et al. (1997) Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch. Neuron 18:133-42
Shao, X; Sudhof, T C; Rizo, J (1997) Assignment of the 1H, 15N and 13C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I. J Biomol NMR 10:307-8
von Poser, C; Ichtchenko, K; Shao, X et al. (1997) The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding. J Biol Chem 272:14314-9
Shao, X; Davletov, B A; Sutton, R B et al. (1996) Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C. Science 273:248-51