This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Periodontal disease and dental caries are ubiquitous in the population. Recent literature has linked oral inflammatory conditions to elevations in circulating inflammatory mediators. In addition, inflammatory mediators such as C-reactive protein have been linked to cardiovascular disease, and a reduction of CRP has been shown to decrease the risk of MI and Stroke. The investigators propose to evaluate the levels of three inflammatory mediators, CRP, IL-6, and fibrinogen, in patients with periodontal disease and dental caries who are having all their teeth removed prior to denture construction. They plan to follow these patients for one year with periodic re-evaluations with venipuncture to establish whether or not there is a decrease in these inflammatory mediators after elimination of oral disease.
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| Ebersole, Jeffrey L; Nagarajan, Radhakrishnan; Akers, David et al. (2015) Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol 5:62 |
| Ewen, Heidi H; Chahal, Jasleen K; Fenster, Emily S (2015) A portrait of resilience in caregiving. Res Gerontol Nurs 8:29-38 |
| Alhurani, Abdullah S; Dekker, Rebecca L; Abed, Mona A et al. (2015) The association of co-morbid symptoms of depression and anxiety with all-cause mortality and cardiac rehospitalization in patients with heart failure. Psychosomatics 56:371-80 |
| Biddle, Martha J; Lennie, Terry A; Bricker, Gregory V et al. (2015) Lycopene dietary intervention: a pilot study in patients with heart failure. J Cardiovasc Nurs 30:205-12 |
| Miller, C S; Foley 3rd, J D; Floriano, P N et al. (2014) Utility of salivary biomarkers for demonstrating acute myocardial infarction. J Dent Res 93:72S-79S |
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