Abstract

While extensive progress has been made over the past decade in finding and treating patients with hypertension, it has become increasingly obvious that long term resolution of this problem will require a greater understanding of the basic mechanisms involved so that preventive measures may be taken. Recent studies have suggested that hypertension is the result of flaws in those systems which normally regulate arterial pressure. The overall objective of this proposal is to pursue studies designed to determine the mechanism(s) responsible for the altered adrenal responses to angiotensin II in essential hypertension and their pathophysiologic significance. Clinical studies will be conducted in patients with essential hypertension and parallel studies in two control groups: normotensive subjects and patients with secondary forms of hypertension.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002635-08
Application #
3090367
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1984-12-01
Project End
1994-11-30
Budget Start
1992-02-14
Budget End
1992-11-30
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Scheuermaier, Karine; Münch, Mirjam; Ronda, Joseph M et al. (2018) Improved cognitive morning performance in healthy older adults following blue-enriched light exposure on the previous evening. Behav Brain Res 348:267-275
Bianchi, Matt T; Phillips, Andrew J K; Wang, Wei et al. (2017) Statistics for Sleep and Biological Rhythms Research. J Biol Rhythms 32:7-17
Swanson, C; Shea, S A; Wolfe, P et al. (2017) 24-hour profile of serum sclerostin and its association with bone biomarkers in men. Osteoporos Int 28:3205-3213
Juraschek, Stephen P; Woodward, Mark; Sacks, Frank M et al. (2017) Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet. Hypertension 70:923-929
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44
Rahman, Shadab A; St Hilaire, Melissa A; Chang, Anne-Marie et al. (2017) Circadian phase resetting by a single short-duration light exposure. JCI Insight 2:e89494
Liu, G; Liang, L; Bray, G A et al. (2017) Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial. Int J Obes (Lond) 41:878-886
Nanba, Kazutaka; Vaidya, Anand; Williams, Gordon H et al. (2017) Age-Related Autonomous Aldosteronism. Circulation 136:347-355
Leuze, Christoph; Aswendt, Markus; Ferenczi, Emily et al. (2017) The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing. Neuroimage 156:412-422
Gupta, Tina; Connors, Molly; Tan, Jia Wei et al. (2017) Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens 31:124-131

Showing the most recent 10 out of 721 publications