Abstract

This study assesses the maturation of the serum antibody response of children to polysaccharide antigens. Serial serum samples from children of various ages will be assayed for antipolysaccharide antibody with respect to IgG subclass distribution and clonal diversity. Throat cultures are obtained to evaluate antigen (pneumococcus, group A beta strep) exposure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006021-02
Application #
3871881
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Thompson, S J; Auslander, W F; White, N H (2001) Comparison of single-mother and two-parent families on metabolic control of children with diabetes. Diabetes Care 24:234-8
Thompson, S J; Auslander, W F; White, N H (2001) Influence of family structure on health among youths with diabetes. Health Soc Work 26:7-14
Arfken, C L; Reno, P L; Santiago, J V et al. (1998) Development of proliferative diabetic retinopathy in African-Americans and whites with type 1 diabetes. Diabetes Care 21:792-5
Auslander, W F; Thompson, S; Dreitzer, D et al. (1997) Disparity in glycemic control and adherence between African-American and Caucasian youths with diabetes. Family and community contexts. Diabetes Care 20:1569-75
Reno, P L; Arfken, C L; Heins, J M et al. (1997) Factors that influence the decision to receive treatment for proliferative diabetic retinopathy. Diabetes Educ 23:653-5
Auslander, W F; Thompson, S J; Dreitzer, D et al. (1997) Mothers' satisfaction with medical care: perceptions of racism, family stress, and medical outcomes in children with diabetes. Health Soc Work 22:190-9
Arfken, C L; Schmidt, L E; McGill, J B et al. (1996) Major decrements in glycated hemoglobin levels between 1978 and 1989 in patients with insulin-dependent diabetes mellitus. J Diabetes Complications 10:12-7
Arfken, C L; Salicrup, A E; Meuer, S M et al. (1994) Retinopathy in African Americans and whites with insulin-dependent diabetes mellitus. Arch Intern Med 154:2597-602
Bonilla-Felix, M; Villegas-Medina, O; Vehaskari, V M (1994) Renal acidification in children with idiopathic hypercalciuria. J Pediatr 124:529-34
Noel, G J; Katz, S L; Edelson, P J (1991) The role of C3 in mediating binding and ingestion of group B streptococcus serotype III by murine macrophages. Pediatr Res 30:118-23