Systematically administered opioids activate bulbospinal noradrenergic pathways. The resulting spinally released norepinephrine activates a2-adrenoceptors on cholinergic neurons, causing ACh release and inhibition of spinal transmission of noxious sensory information. This hypothesis suggests that i.t. neostigmine, by enhancing spinal cholinergic activity, should potentiate analgesia from intraspinal a-adrenergic agonist and from systemic opioids.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
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