This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective cohort study of the predictors of functional aging using HS participants be assessed in a follow-up exam and defined as having intact physical and cognitive function at the examination. Prior data will be examined as predictors of function and continuous measures of function. In a nested case-control study, we will assay new markers with an emphasis on oversampling the oldest participants. Continued telephone follow-up will be conducted to improve power in the very old. Intact physical function will be defined as self report of no difficulty and observed independence with activities of daily living (basic self-care skills or ADLs), while intact cognitive function will require a score of 80 or more on the Modified Mini Mental State Exam (3MSE). Continuous scales of physical performance and cognitive functioning that can be measured in the home or clinic setting will capture a full range of normal and also very high function. Longitudinal data from prior CHS exams conducted from 1989-1999 and telephone interviews from 1999-2003 will be used as predictors of function. We will continue to follow the cohort forward at 6 month intervals in order to also prospectively define rates of maintaining function.
Showing the most recent 10 out of 577 publications
