Learning is how organisms adapt to changes in their environment and involves the coordination of neural systems mediating cognition, emotion, and motor control. The major goal of the proposed research program is to elucidate the neural circuit mechanisms underlying interactions between cognitive, emotional, and motor systems during associative learning. Interactions between these neural systems are particularly important because the context and emotional significance of stimuli provide essential information for acquisition and performance of motor responses. The breakdown of interactions between cognitive, emotional, and motor systems in various neurological disorders can therefore have devastating consequences for learned behaviors. The prefrontal cortex, amygdala, and cerebellum play significant roles in cognition, emotional responses, and motor learning, respectively. The proposed research program constitutes a comprehensive analysis of cerebellar interactions with the amygdala and prefrontal cortex during associative motor learning. Our general conceptual framework is that the cerebellum receives inputs from the amygdala and prefrontal cortex via the pons regarding which stimuli are important and when they occur, and the cerebellum then sends error-driven feedback to these forebrain systems to facilitate learning about important events. This conceptual framework takes into account the bidirectional relationship between the cerebellum and the relevant forebrain systems as well as interactions between forebrain systems. Multi-site electrophysiology, pathway-specific optogenetics, and precise behavioral analyses will be combined to investigate circuit-level interactions between the cerebellum, amygdala, and prefrontal cortex during associative learning and extinction (inhibitory learning) training. The proposed studies would significantly advance understanding of the neural circuit mechanisms underlying cerebellar interactions with the forebrain. This would be a substantial contribution to the field because it has been known that the cerebellum must interact with the forebrain in many contexts that are crucial for everyday life such as learning, memory, planning, control of emotions, and communication, but very little is known mechanistically about how the cerebellum interacts with the amygdala and prefrontal cortex.

Public Health Relevance

Memory deficits are found with many neurological disorders such as Alzheimer's disease and following stroke; the breakdown of interactions between memory systems can be particularly debilitating. This proposal examines the neural mechanisms underlying interactions between emotional and motor memory systems during associative learning. Elucidating the neural mechanisms underlying memory system interactions is potentially important for developing treatments for memory deficits.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS088567-07
Application #
10069403
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Babcock, Debra J
Project Start
2015-02-01
Project End
2025-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
7
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Iowa
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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