This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.About 80% of Type 2 diabetic patients develop end-stage kidney disease. The presence of microalbuminuria is associated with a three to five -fold greater risk of cardiovascular mortality. Currently there are no markers that predict which patients with diabetes will develop microalbuminuria. This study will determine urinary catalytic iron and a marker of oxidative stress (urinary isoprostanes) in patients with normal albumin excretion rate and examine the ability of these markers to predict the probability of developing microalbuminuria. The purpose of this study is to determine if these 2 urinary markers (catalytic iron and urinary isoprostanes) predict who is likely to develop diabetes-related kidney disease.
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