The mechanisms underlying non-insulin dependent diabetes mellitus (NIDDM) remain controversial and, despite progress in the molecular genetics of NIDDM, the mechanisms are unknown for >85% of patients. This project assesses the relationship of hyperproinsulinemia to insulin secretory function in a population at high risk for progression to NIDDM, namely euglycemic women with previous gestational diabetes (GDM) as a potential marker for localizing beta cell defects to steps which do versus those that do not impact on post-translational processing of the insulin gene product.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
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