This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this study include 1) a prospective collection of clinical and epidemiological data concerning acute liver failure and 2) the collection of serum and tissue samples on the same cohort of patients. These data will be used to analyze trends, to develop prognostic information, as well as to provide materials to investigators in this field. The overall aim is to provide a comprehensive approach to the study of acute liver failure and to impact significantly the outcome of patients in the United States with this life-threatening disease. All patients regardless of age, race or gender who present with acute liver failure and meet defined clinical criteria are eligible for enrollment in this Multi-center Acute Liver Failure (ALF) Study. Standardized admission and outcome data collection forms will be completed on all enrolled patients. Serum samples will be collected daily for the first 7 days following enrollment or until transplantation or death, whichever occurs first. Samples of liver tissue will be collected from clinically indicated biopsies, liver explants or autopsies. Serum and tissue will be shipped to the ALF Study Group central storage site in Dallas, TX.
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