This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There has been much recent interest in medical morbidity associated with posttramatic stress disorder(PTSD). Cardiovascular response being a prominent feature of the phyciological reactivity that is a core feature of the disorder raises the possibility of enduring effects on cardiovascular function. Studies are mixed as to whether PTsd is associated with an increased risk of hypertension and related cardiovascular morbidity. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejuice and discrimination. In a subsequent phase of the research we will also evalute relationships to genetic polymorphisms of adrenergic receptors.
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