Abstract

We hypothesize that molecular defects in one or a few genes segregate among normoglycemic offspring of families with multiple type 2 diabetic siblings and result in the components of the insulin resistance syndrome: hyperinsulinemia, elevated free fatty acid levels, and diminished insulin sensitivity. These defects represent an intermediate, prediabetic state that increases the risk of type 2 diabetes among offspring and siblings of diabetic individuals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR014288-02
Application #
6406566
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1999-08-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Serra, Monica C; Blumenthal, Jacob B; Addison, Odessa R et al. (2017) Effects of Weight Loss with and without Exercise on Regional Body Fat Distribution in Postmenopausal Women. Ann Nutr Metab 70:312-320
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2015) Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults. J Gerontol A Biol Sci Med Sci 70:91-6
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2014) Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci 69:363-70
Herrick, Jeffrey E; Bliwise, Donald L; Puri, Shipra et al. (2014) Strength training and light physical activity reduces the apnea-hypopnea index in institutionalized older adults. J Am Med Dir Assoc 15:844-6
Conley, Travis B; McCabe, George P; Lim, Eunjung et al. (2013) Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data. J Nutr Biochem 24:693-9
Mondal, Ashis K; Sharma, Neeraj K; Elbein, Steven C et al. (2013) Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics 45:509-20
Sharma, Neeraj K; Langberg, Kurt A; Mondal, Ashis K et al. (2013) Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One 8:e65303
Lorenz, Rebecca A; Gooneratne, Nalaka; Cole, Catherine S et al. (2012) Exercise and social activity improve everyday function in long-term care residents. Am J Geriatr Psychiatry 20:468-76
Thrailkill, K M; Jo, C-H; Cockrell, G E et al. (2012) Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes. Osteoporos Int 23:1799-806

Showing the most recent 10 out of 164 publications