We hypothesize that molecular defects in one or a few genes segregate among normoglycemic offspring of families with multiple type 2 diabetic siblings and result in the components of the insulin resistance syndrome: hyperinsulinemia, elevated free fatty acid levels, and diminished insulin sensitivity. These defects represent an intermediate, prediabetic state that increases the risk of type 2 diabetes among offspring and siblings of diabetic individuals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR014288-02
Application #
6406566
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1999-08-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
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