Abstract

The purpose of the study is to address the issue of how alterations in arterial stiffness that occur with adult aging affect the myocardium. The interaction of age, arterial pressure, and vascular stiffness on myocardial structure and function shall be addressed by simultaneous measurements of those parameters in a population that is genetically homogeneous but is comprised of individuals in a broad age range who exhibit a spectrum of arterial stiffness. The study population shall consist of a minimum of 800 individuals of each sex evenly distributed across the age range of 20 to 90-100 years who are free of clinical diseases (except hypertension) that can affect arterial or cardiac properties.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG012118-002
Application #
2294080
Study Section
Project Start
1991-09-30
Project End
1993-12-31
Budget Start
1993-05-28
Budget End
1993-12-31
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Wang, Kang-Ling; Cheng, Hao-Min; Sung, Shih-Hsien et al. (2010) Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study. Hypertension 55:799-805
Farasat, S Morteza; Morrell, Christopher H; Scuteri, Angelo et al. (2008) Do hypertensive individuals have enlarged aortic root diameters? Insights from studying the various subtypes of hypertension. Am J Hypertens 21:558-63
Farasat, S Morteza; Morrell, Christopher H; Scuteri, Angelo et al. (2008) Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension. Hypertension 51:196-202
Chen, C H; Ting, C T; Lin, S J et al. (1998) Which arterial and cardiac parameters best predict left ventricular mass? Circulation 98:422-8
Chen, C H; Hsu, T L; Lin, S J et al. (1995) Short-term and long-term effects of benazepril in mild to moderate hypertensives. Zhonghua Yi Xue Za Zhi (Taipei) 56:12-22
Chen, C H; Ting, C T; Lin, S J et al. (1995) Different effects of fosinopril and atenolol on wave reflections in hypertensive patients. Hypertension 25:1034-41
Sharir, T; Marmor, A; Ting, C T et al. (1993) Validation of a method for noninvasive measurement of central arterial pressure. Hypertension 21:74-82