Abstract

The primary objective of the study is to examine the incidence of physical disability in relation to body composition and weight-related health conditions in healthier older persons. Change in body composition in old age, particularly loss of muscle mass and bone, may be a common pathway by which multiple diseases contribute to risk of disability. The reasons for changes in weight and body composition in old age and the influence of these changes in health outcomes are not fully understood. The HEALTH ABC will include a total of 3,000 noninstitutionalized white and African- American men and women aged 70-79.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG062106-004
Application #
2660212
Study Section
Project Start
1996-03-29
Project End
2004-06-30
Budget Start
1997-09-23
Budget End
1999-09-30
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Organized Research Units
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Sparto, Patrick J; Newman, A B; Simonsick, E M et al. (2018) Contributions to lateral balance control in ambulatory older adults. Aging Clin Exp Res 30:633-641
Xu, Jiayi; Bartz, Traci M; Chittoor, Geetha et al. (2018) Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. Br J Nutr 120:1159-1170
Floyd, J S; Sitlani, C M; Avery, C L et al. (2018) Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. Pharmacogenomics J 18:127-135
Seyerle, A A; Sitlani, C M; Noordam, R et al. (2018) Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J 18:215-226
Manini, Todd M; Buford, Thomas W; Kairalla, John A et al. (2018) Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. Geroscience 40:497-511
Nowak, Kristen L; Fried, Linda; Jovanovich, Anna et al. (2018) Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol 47:57-65
Barbour, Kamil E; Sagawa, Naoko; Boudreau, Robert M et al. (2018) Knee Osteoarthritis and the Risk of Medically Treated Injurious Falls among Older Adults: the Health ABC Study. Arthritis Care Res (Hoboken) :
Hong, Jaeyoung; Hatchell, Kathryn E; Bradfield, Jonathan P et al. (2018) Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. J Clin Endocrinol Metab 103:1380-1392
Segna, D; Bauer, D C; Feller, M et al. (2018) Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283:56-72

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