Project Start
2000-06-26
Project End
2005-06-25
Budget Start
2000-06-26
Budget End
2001-06-25
Support Year
Fiscal Year
2000
Total Cost
$3,773,578
Indirect Cost
Name
Wyeth-Lederle Vaccines
Department
Type
DUNS #
City
West Henrietta
State
NY
Country
United States
Zip Code
14586
Megati, Shakuntala; Garcia-Hand, Dorys; Cappello, Sarah et al. (2008) Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses. Vaccine 26:5083-94
Gao, Feng; Liao, Hua-Xin; Hahn, Beatrice H et al. (2007) Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr HIV Res 5:572-7
Chong, Siew-Yen; Egan, Michael A; Kutzler, Michele A et al. (2007) Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine 25:4967-82
Egan, Michael A; Megati, Shakuntala; Roopchand, Vidia et al. (2006) Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice. Vaccine 24:4510-23
Schadeck, Eva B; Sidhu, Maninder; Egan, Michael A et al. (2006) A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques. Vaccine 24:4677-87
Haynes, Barton F; Ma, Benjiang; Montefiori, David C et al. (2006) Analysis of HIV-1 subtype B third variable region peptide motifs for induction of neutralizing antibodies against HIV-1 primary isolates. Virology 345:44-55
Kim, Mikyung; Qiao, Zhi-Song; Montefiori, David C et al. (2005) Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies. AIDS Res Hum Retroviruses 21:58-67
Egan, Michael A; Chong, Siew Yen; Megati, Shakuntala et al. (2005) Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus. AIDS Res Hum Retroviruses 21:629-43
Liao, Hua-Xin; Alam, S Munir; Mascola, John R et al. (2004) Immunogenicity of constrained monoclonal antibody A32-human immunodeficiency virus (HIV) Env gp120 complexes compared to that of recombinant HIV type 1 gp120 envelope glycoproteins. J Virol 78:5270-8
Gao, Feng; Korber, Bette T; Weaver, Eric et al. (2004) Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. Expert Rev Vaccines 3:S161-8

Showing the most recent 10 out of 12 publications