Abstract

The eastern woodchuck (Marmota monax) infected by the Woodchuck Hepatitis Virus (WHV) is a well-characterized infection model paralleling the disease processes of human hepatitis B virus infection The AALAC-accredited colony at Cornell is entirely house bred according to genealogy thus preventing the potential anomalies of using wild-caught animals. As such it is considered the """"""""gold standard"""""""" model in which to test new and established antiviral agents both singly and in combination. It is also used as a model to identify both viral and host responses to infection, pathogenesis, immune responses, and viral resolution. Promising candidate antivirals tested initially in well-defined in vitro screens can subsequently move into in vivo testing through the HBV Animal Model Network-a consortium of three contracts involved in this endeavor.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI005399-000
Application #
6324182
Study Section
Project Start
2000-01-01
Project End
2004-09-29
Budget Start
2000-01-01
Budget End
2000-09-29
Support Year
Fiscal Year
2000
Total Cost
$1,420,336
Indirect Cost

  Institution

Name
Cornell University
Department
Other Clinical Sciences
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Moreno-Cugnon, Leire; Esparza-Baquer, Aitor; Larruskain, Amaia et al. (2015) Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in the Marmota monax, animal model of hepatitis B. Mol Immunol 63:505-12
Menne, Stephan; Tumas, Daniel B; Liu, Katherine H et al. (2015) Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. J Hepatol 62:1237-45
Ochoa-Callejero, Laura; Toshkov, Ilia; Menne, Stephan et al. (2013) Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma. J Med Virol 85:1127-38
Freitas, Natalia; Salisse, Jessica; Cunha, Celso et al. (2012) Hepatitis delta virus infects the cells of hepadnavirus-induced hepatocellular carcinoma in woodchucks. Hepatology 56:76-85
Fletcher, Simon P; Chin, Daniel J; Ji, Yongmei et al. (2012) Transcriptomic analysis of the woodchuck model of chronic hepatitis B. Hepatology 56:820-30
Liu, Katherine H; Ascenzi, Mary A; Bellezza, Christine A et al. (2011) Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks. J Virol 85:4853-62
Norton, Pamela A; Menne, Stephan; Sinnathamby, Gomathinayagam et al. (2010) Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. Hepatology 52:1242-50
Glebe, Dieter; Lorenz, Heike; Gerlich, Wolfram H et al. (2009) Correlation of virus and host response markers with circulating immune complexes during acute and chronic woodchuck hepatitis virus infection. J Virol 83:1579-91
Rodriguez-Madoz, Juan R; Liu, Katherine H; Quetglas, Jose I et al. (2009) Semliki forest virus expressing interleukin-12 induces antiviral and antitumoral responses in woodchucks with chronic viral hepatitis and hepatocellular carcinoma. J Virol 83:12266-78
Cote, Paul J; Butler, Scott D; George, Andrea L et al. (2009) Rapid immunity to vaccination with woodchuck hepatitis virus surface antigen using cationic liposome-DNA complexes as adjuvant. J Med Virol 81:1760-72

Showing the most recent 10 out of 28 publications