Abstract

Maintain, manage and evaluate a multicenter clinical trials group for evaluation of antifungal therapies. Develop and coordinate multicenter clinical trials for antifungal therapies. Maintain a data management and analysis system for the multicenter trials performed by the group. Maintain on-site monitoring to ensure completeness and accuracy of study data and adherence with established research standards and protocol requirements. Organize and conduct an annual Investigators' Meeting which will include presentation and review of data, updates on the progress of all studies, discussion of proposed protocols and establishment of the group's research priorities and standard procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI015082-010
Application #
2294891
Study Section
Project Start
1990-10-08
Project End
1995-10-07
Budget Start
1993-12-16
Budget End
1994-10-07
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Dismukes, William E (2006) Antifungal therapy: lessons learned over the past 27 years. Clin Infect Dis 42:1289-96
Larsen, Robert A; Bauer, Madeline; Thomas, Ann M et al. (2004) Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis. Antimicrob Agents Chemother 48:985-91
Arani, R B; Soong, S J; Weiss, H L et al. (2001) Phase specific analysis of herpes zoster associated pain data: a new statistical approach. Stat Med 20:2429-39
Galgiani, J N; Catanzaro, A; Cloud, G A et al. (2000) Comparison of oral fluconazole and itraconazole for progressive, nonmeningeal coccidioidomycosis. A randomized, double-blind trial. Mycoses Study Group. Ann Intern Med 133:676-86
Robinson, P A; Bauer, M; Leal, M A et al. (1999) Early mycological treatment failure in AIDS-associated cryptococcal meningitis. Clin Infect Dis 28:82-92
Diamond, D M; Bauer, M; Daniel, B E et al. (1998) Amphotericin B colloidal dispersion combined with flucytosine with or without fluconazole for treatment of murine cryptococcal meningitis. Antimicrob Agents Chemother 42:528-33
Wheat, J; Marichal, P; Vanden Bossche, H et al. (1997) Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum. Antimicrob Agents Chemother 41:410-4
Edwards Jr, J E; Bodey, G P; Bowden, R A et al. (1997) International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections. Clin Infect Dis 25:43-59
Wheat, J; MaWhinney, S; Hafner, R et al. (1997) Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group. Am J Med 103:223-32
Ding, J C; Bauer, M; Diamond, D M et al. (1997) Effect of severity of meningitis on fungicidal activity of flucytosine combined with fluconazole in a murine model of cryptococcal meningitis. Antimicrob Agents Chemother 41:1589-93

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