This contract shall make available the invaluable experience of the Principal Investigator and her co-investigators in the use of the SIV:macaque model for HIV vaccine development. Specifically, this contract shall provide the facilities and expertise to evaluate prospective SIV vaccines in up to 100 rhesus monkeys/year. Monkeys will be immunized, evaluated for both cellular and humoral immune responses to vaccination, and challenged with titered stocks of live virus. Infection which may arise post challenge will be determined by virus re-isolation, polymerase chain reaction amplification of proviral DNA, and serology. All animals will be provided 24 hour veterinary care in a facility accredited by the American for Accreditation of Laboratory Animal Care. Virus stocks to be used for challenge of vaccinates may be prepared and titered in vivo as required. It is hoped that this contract shall provide a systematic analysis of viable vaccine strategies in the nonhuman primate model for AIDS such that implementation of efficacious vaccines in human trials may be expedited.

Project Start
1990-12-31
Project End
1995-12-30
Budget Start
1995-06-21
Budget End
1995-12-30
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
Other Domestic Higher Education
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Ohkawa, S; Wilson, L A; Larosa, G et al. (1994) Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. AIDS Res Hum Retroviruses 10:27-38